• The molecular mechanisms underlying VSMC ETB

  2022-07-22

  

  The molecular mechanisms underlying VSMC ETB receptor upregulation have been studied after 24–48h organ culture in both coronary and cerebral arteries. The increased expression of contractile ETB receptor at these time points has been shown to depend on transcriptional mechanisms and PKC and the ext

• One limitation of our study was that all control

  2022-07-22

  

  One limitation of our study was that all control dogs had histologic evidence of mild GI inflammation according to established WSAVA guidelines (Washabau et al., 2010), despite being apparently healthy purpose-bred research dogs housed in a controlled environment with no history of vomiting, diarrhe

• In this study we also profiled the expression

  2022-07-22

  

  In this study, we also profiled the expression of the transporters in wild-type RBL-2H3 cells, RBL-2H3 Sc98 cells, and rat peritoneal mast cells. OCT1 and PMAT were expressed at high levels in both RBL-2H3 Sc98 and RBL-2H3 cells. However, OCT2 and OCT3 were weakly or least detected in RBL-2H3 Sc98 c

• br Tissue Specific Roles for HIF PHD Isoforms Hypoxia signal

  2022-07-22

  

  Tissue-Specific Roles for HIF/PHD Isoforms Hypoxia signaling pathways are active in almost all mammalian cells, including immune Benazepril HCl and tissues such as the epithelium and endothelium. This is of crucial importance when considering the influence of environmental hypoxia in inflammator

• br Conclusion br Funding br Availability of

  2022-07-22

  

  Conclusion Funding Availability of data and materials Authors' contributions Ethics approval and consent to participate Consent for publication Competing interests Introduction Hepatitis C virus (HCV) infection is a global public health problem. An estimated 71.1 million peop

• The stress of accelerated lactate production in

  2022-07-22

  

  The stress of accelerated lactate production in cancer cyclohexamide is moderated by the overexpression of lactate transporters – symporters for lactate anions and protons called monocarboxylate transporters (MCTs) – that are capable of bidirectional transport depending on the environmental and/or

• To further explain the energy differences between

  2022-07-21

  

  . To further explain the energy differences between Group-A and Group-B, the average distances between ligands and the zinc cation were obtained from the last 1ns trajectory. It turns out that the members of group A were within the coordination distance of the zinc ion, whereas those of group B stay

• Although glycine receptors predominate in the brain

  2022-07-21

  

  Although glycine receptors predominate in the brain stem and spinal cord, they are also expressed in higher brain regions such as the nucleus accumbens, frontal cortex, and hippocampus (Jonsson et al., 2012, Jonsson et al., 2009, Molander and Söderpalm, 2005b). A variety of drugs of abuse, including

• On the other hand we have previously demonstrated

  2022-07-21

  

  On the other hand, we have previously demonstrated that gelsemine displaced the H3-strychnine from membrane fractions of rat spinal cord homogenates. In addition, spinal gelsemine antinociception was blocked by intrathecal injection of the specific glycine receptor antagonist strychnine or gene sile

• It is known that hypercapnia as well as hypoxia can

  2022-07-21

  

  It is known that hypercapnia, as well as hypoxia, can result in a decrease in body temperature, but the mechanisms involved are not very well known (Barros and Branco, 1998; Saiki and Mortola, 1996). One D-Pantothenic acid australia is that when there is an acute hypercapnic exposure, acidosis play

• br Acknowledgements This work was

  2022-07-21

  

  Acknowledgements This work was supported by the National Institutes of Health [grant number GM024417]. Introduction In mammals, glucose is the major energy substrate supporting conceptus development after Ursodiol receptor formation [1,2]. While the equine morula uses similar amounts of pyruv

• br Methods br Results br Discussion Among

  2022-07-21

  

  Methods Results Discussion Among three main signaling pathways activated by bFGF, the MAPK pathway was found to be involved in the upregulation of GR levels. So far, there have been a few candidates that could connect activated ERK to the upregulation of GR. One likely candidate is the zin

• Irpex lacteus was well known as an

  2022-07-21

  

  Irpex lacteus was well known as an edible and medicinal mushroom. It had been reported that I. lacteus could produce a thermostable α-galactosidase [17]. The reported α-galactosidase from I. lacteus, however, seemed to be unsuitable for the practical application due to its poor hydrolysis ability to

• br Methods br Results It is well

  2022-07-21

  

  Methods Results It is well known that during the onset of vasoconstriction there is an increase in intracellular Ca2+ which activates myosin light-chain kinase followed by cycling of actin-myosin cross-bridges in VSMCs. Recently, it has been recognized that Nitazoxanide polymerization is also

• br STAR Methods br Introduction Arsenite is a well recognize

  2022-07-21

  

  STAR★Methods Introduction Arsenite is a well-recognized toxic metalloid that commonly presents in the natural environment. Chronic exposure to arsenite can lead to a wide range of adverse health effects to human, including cancers, cardiovascular diseases, diabetes, skin lesion and neurodegene

11495 records 98/767 page Previous Next First page 上5页 96979899100 下5页 Last page