• On the other hand a major advantage of this

  2018-10-24

  

  On the other hand, a major advantage of this alternative double-reporter genetic model is to provide a clear-cut qualitative answer as to whether new CMs are formed after injury and if so, whether these new CMs originated predominantly from pre-existing CMs or from another cell population. If no new

• TSA a HDAC inhibitor has a

  2018-10-24

  

  TSA, a HDAC inhibitor, has a differential affinity to bind various HDAC complexes (Bantscheff et al., 2011). In the present study, ChIP analysis revealed that HDAC2 and HDAC3 are bound with higher affinity to the Cyclin B1 promoter in BMSCs and the Cyclin D2 promoter in HSPCs, which inhibits the exp

• In summary these perivascular derivatives demonstrate an imp

  2018-10-24

  

  In summary, these perivascular derivatives demonstrate an important building block toward not only reconstructing physiologically relevant vasculature but also the study of developmental processes and diseases implicating these cell types. Important elements of our system are the several noted discr

• Given the importance of ROCK signaling in hESC

  2018-10-24

  

  Given the importance of ROCK signaling in hESC survival, it is likely that mutations affecting the activity or expression of multiple genes in this pathway could confer a competitive advantage to mutant cells. Indeed, neither of the adapted sublines of H7 or H14 was significantly influenced at any o

• These findings indicate that cells of different developmenta

  2018-10-24

  

  These findings indicate that vegfr inhibitor of different developmental origins can converge to generate somatic tissue precursor cells with highly similar phenotypes. However, they also raise a number of important questions. In particular, while it is generally thought that only the neural crest g

• br Results and Discussion br

  2018-10-24

  

  Results and Discussion Conclusions Experimental Procedures Acknowledgments Introduction The cancer stem cell (CSC) model suggests that whereas most tumor dihydrochloride cost are destined to differentiate, albeit aberrantly, a small subset of tumor cells, termed CSCs, actively sustai

• Main Text br Acknowledgments The authors would

  2018-10-24

  

  Main Text Acknowledgments The authors would like to thank all delegates for their input into the workshops that led to the contents of this white paper (Table S2). Introduction The type II clustered regularly interspaced short palindromic repeat (CRISPR) systems and the associated Cas9 nucle

• br Introduction Advances in stem cell based therapies

  2018-10-24

  

  Introduction Advances in stem-cell-based therapies may help overcome CNS disorders such as spinal cord injury (SCI). Transplantation of neural stem/progenitor pdk1 (NS/PCs) has yielded beneficial effects and improved functional recovery in SCI animal models (Cummings et al., 2005; Hofstetter et 

• The pluripotency of the RbiPSC line

  2018-10-24

  

  The pluripotency of the RbiPSC line was examined by immunocytochemistry staining, using nitric oxide synthase inhibitor against human OCT4, SOX2, and SSEA4 (Fig. 1A). The in vitro spontaneous differentiation potential towards the three germ layer of RbiPSC line was demonstrated by the expression of

• In conclusion the MC approach described

  2018-10-24

  

  In conclusion, the MC approach described in this study provides a platform to generate a population of human PAX7+ myogenic progenitors from PS tegaserod that can be terminally differentiated into MHC+ myocytes in vitro that is equivalent to iPAX7 cells. However, further development of the methodolo

• Theoretically enhanced induction of TRA

  2018-10-24

  

  Theoretically, enhanced induction of TRA1-60, a specific marker for reprogrammed iPSCs by miR-31 and shRNA-SDHA, can be achieved in two ways: improved reprogramming efficiency or inhibiting pariPSCs from differentiating back into somatic cells. We strongly favor the view that enhanced induction of T

• br Results br Discussion Extensive microarray datasets have

  2018-10-24

  

  Results Discussion Extensive microarray datasets have been published previously. The ImmGen consortium offers unique data that were generated by multiple groups following a unified and strict protocol. We have previously analyzed this dataset to reveal genes that are preferentially expressed i

• To study the cellular and molecular events

  2018-10-24

  

  To study the cellular and molecular events of FTD3, we derived a disease model using human iPSCs from patients carrying the 31449G > C mutation in CHMP2B and isogenic controls generated via the CRISPR/Cas9 system with subsequent in vitro neuronal differentiation. Our model not only confirmed partly

• br Results br Discussion In

  2018-10-24

  

  Results Discussion In this work, we confirm that pnPRX1+ AMG-517 of the calvaria presented gene expression profiles of SSC\'s, are localized to the calvarial suture niche, and are required for calvarial bone regeneration. Global ablation strategies of SSCs do not allow to unequivocally conclu

• The electrostatic spectrographs are not yet industrially man

  2018-10-24

  

  The electrostatic spectrographs are not yet industrially manufactured and the devices proposed are rather the experimental models (see Refs. [2, 4–6]). A theory for designing potential structures where the spectrographic mode is implemented has been developed at our Laboratory of Corpuscular Optic

11494 records 762/767 page Previous Next First page 上5页 761762763764765 下5页 Last page