• Pharmacokinetics analysis of AT on SCID

  2019-06-06

  

  Pharmacokinetics analysis of AT-406 on SCID mice bearing MDA-MB-231 tumors has shown that AT-406 achieves a maximum concentration in plasma between 1.5μM and 9.9μM, and a maximum concentration in tumor tissue between 0.5μM and 18.2μM, depending on the dose and administration route (intravenous versu

• Introduction Acute erythroleukemia AEL is a rare subtype

  2019-06-06

  

  Introduction Acute erythroleukemia (AEL) is a rare subtype of acute myeloid leukemia (AML), accounting for 3–5% of all AML cases. It is characterized by the expansion of erythroblasts in the bone marrow (BM). Its clinical presentation often resembles myelodysplastic syndromes (MDS), both in terms o

• Upon diagnosis the patient s lymphoma and

  2019-06-06

  

  Upon diagnosis, the patient׳s lymphoma and HLH represented a therapeutic dilemma. Effective early therapy reduces mortality of HLH from 95% to 30–35% [4]. The HLH-2004 treatment protocol consists of T-cell targeted immunosupression with dexamethasone and cyclosporine, macrophage targeted etoposide w

• years ago published a groundbreaking and taboo breaking Seri

  2019-06-06

  

  5 years ago, published a groundbreaking (and taboo-breaking) Series on stillbirths. Its powerful mix of advocacy and hard data attracted more media attention than perhaps any other Series, and made waves on numerous levels, from the individual to the intergovernmental. Working closely with countrie

• br In a Comment February we argued that

  2019-06-06

  

  In a Comment (February, 2017), we argued that action on the conditions currently referred to as non-communicable diseases (NCDs) may be hampered by the inadequacy of their label. We received a remarkable amount of feedback on this suggestion, and in this Comment we synthesise the responses garnere

• Most infants in NICUs are hospitalized continuously from bir

  2019-06-06

  

  Most infants in NICUs are hospitalized continuously from birth, and MRSA infections are largely considered to be horizontally transmitted. Various studies had reported that viable MRSA can be found on the hands of up to 17% of healthcare workers, and on 59% of the environmental surfaces in rooms of

• br Conflict of interest br Case presentation A year old

  2019-06-06

  

  Conflict of interest Case presentation A 64-year-old female presented to the emergency room with persistent dizziness that began early that morning. She had a 30-year history of palpitations and known electrocardiogram (ECG) abnormalities. Her pulse was irregular at 130–270min−1 and blood pres

• The standard therapy for chordoma is

  2019-06-06

  

  The standard therapy for chordoma is excision. Local recurrence, but not metastasis, is a major determinant of prognosis. Because local recurrence is related to initial surgical margin and intra-operative tumor cell contamination, achieving a safe margin is very important. Boriani [6] reported 153 c

• En Por qu construir un pueblo es la tarea de

  2019-06-06

  

  En “\"Por qué construir un pueblo es la tarea de la política radical?”, Laclau profundiza una tensión en su teoría en el marco de la respuesta mek inhibitor Slavoj zžek. Por un lado, la formalidad de la lógica populista, en principio, impide predicar sus alcances en cuanto a la democracia (tanto en

• En otra rbita George Y dice

  2019-06-06

  

  En otra órbita, George Yúdice establece una doble genealogía refiriéndose al testimonio que se realiza jnk inhibitor partir de la información que proporciona un sujeto subalterno a un escritor o a un intelectual. Yúdice se refiere aquí a la pedagogía de los oprimidos de Paulo Freire y a la Teología

• br Reflexiones finales En el presente art culo hemos

  2019-06-05

  

  Reflexiones finales En el presente artículo hemos analizado a la Virgen de caacupé como proceso de construcción social identitaria. para ello hemos abordado el traslado y refundación de la devoción por parte de los migrantes paraguayos a la ciudad de San carlos de Bariloche. este proceso en tant

• br In the cluster randomised

  2019-06-05

  

  In the cluster randomised controlled trial by Marcel Yotebieng and colleagues (August, 2015) the addition of Step 10 of the UNICEF Baby Friendly Hospital Initiative (BFHI)—that is, the provision of additional support for breastfeeding—did not enhance the effects of steps 1–9, and may even have les

• It was imperative to make patients a first

  2019-06-05

  

  It was imperative to make patients a first priority who had a definitive diagnosis needing immediate, timely, and effective interventions, including primary coronary intervention (PCI), permanent hiv protease inhibitors implantation, and were most likely to be admitted to CCU postprocedurally (Tabl

• br The indications for ICD placement

  2019-06-05

  

  The indications for ICD placement for the secondary prevention of sudden cardiac death Some patients with underlying prostaglandin receptor disease and/or LV dysfunction die from tachyarrhythmias even after ICD placement [18]. However, no arrhythmic deaths occurred during the implantation or dur

• br Conclusion br Acknowledgments br Introduction The bone is

  2019-06-05

  

  Conclusion Acknowledgments Introduction The bone is the most common site of tumor metastasis, in about 20–25% of cancer patients [1]. Bone metastases are most common from carcinomas of the breast, lung, prostate, kidney, and thyroid. Some bone metastases are osteoclastic, whereas others are

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