• The findings of increased ERK

  2020-08-08

  

  The findings of increased ERK in the medial prefrontal cortex in our previous apomorphine context specific sensitization and conditioning studies [26,27] and the present results appear supportive of evidence that dopamine projection sites contribute to dopamine effects upon learning and memory proce

• br Due to the sequence conservation between

  2020-08-08

  

  Due to the sequence conservation between NEDD8 and ubiquitin, neddylation and ubiquitylation could be similarly complex with regard to substrate number, modifications and diversity of cellular functions. The biochemical identification of neddylated proteins, besides Cullins, is hampered by the fac

• Methylcobalamin receptor FBXO an F box protein family member

  2020-08-07

  

  FBXO1, an F-box protein family member, is a substrate-recognition subunit of the SCF-type E3 ubiquitin ligase. A recent genomic study revealed that expression of CCNF gene encoding FBXO1 can lead to aberrant ubiquitination and affect the mechanisms of neuronal degeneration in amyotrophic lateral scl

• br Assessing DUB activity The Ub

  2020-08-07

  

  Assessing DUB activity The Ub field has benefited greatly from the past efforts of biochemists and chemical biologists who have reconstituted Ub signals in vitro and generated tools for capturing or measuring DUB activities, many of which can be readily produced or are commercially available (Ekk

• In our current work we have undertaken liquid phase combinat

  2020-08-07

  

  In our current work, we have undertaken liquid phase combinatorial synthesis methods for the synthesis of 1,2,5-trisubstituted benzimidazole derivatives as hDHODH inhibitors. Synthesised Procainamide HCl were also screened by molecular docking studies over the reported hDHODH structure. The synthes

• In addition to providing insights about promiscuous

  2020-08-07

  

  In addition to providing insights about promiscuous kinases in general, the results presented here suggest a molecular mechanism for the unusually low kinase activity of DDR1 (Leitinger, 2014). Among promiscuous kinases, Tyr755 is only present in DDR1 and DDR2. This tyrosine is part of DDR1/2\'s Yxx

• Altogether we have shown the presence of

  2020-08-06

  

  Altogether we have shown the presence of fully methylated DAPK fragments in serum of ovarian cancer patients but also of women with uterine leiomyoma. This indicates the prerequisite for the analysis of not only healthy controls but also of women with other frequent non-cancer disease for the valida

• CYP reaction phenotyping showed that piperine and SCT

  2020-08-06

  

  CYP450 reaction phenotyping showed that piperine and SCT-29 are cleared by a single enzyme, CYP1A2 and CYP2C9, respectively, and thus are more sensitive to drug–drug interactions. CYP2C9 contributed significantly in the oxidative metabolism of all analogs. Genetic polymorphism of CYP2C9 may lead to

• Chrysin synthesis Introduction Quassinoids are natural produ

  2020-08-06

  

  Introduction Quassinoids are natural products formed through the oxidative degradation of triterpene derivatives with anti-inflammatory, antimicrobial, antineoplastic, and antiplasmodial effects (Chakraborty and Pal, 2013; Houël et al., 2013). They are characteristic ingredients of the family Simar

• In eukaryotic cells progression through cell cycle

  2020-08-06

  

  In eukaryotic cells, progression through cpi 1 synthesis is dependent on the activity of Cdks (Pavletich, 1999; Malumbres and Barbacid, 2005; Li et al., 2015), a group of proline directed proteins that are inactive as monomers (Peyressatre et al., 2015; Li et al., 2015), and are activated upon asso

• nuciferine br Acknowledgements br Introduction Autism is a n

  2020-08-06

  

  Acknowledgements Introduction Autism is a neurodevelopmental disorder, and in which its main diagnostic symptoms are unfamiliar common social interactions, with intense deficiencies in social cognition in several cases (Chevallier et al., 2012, Constantino, 2011). Improper understanding of soc

• The dilute gas viscosity is defined

  2020-08-06

  

  The dilute gas viscosity (ηο) is defined as the viscosity zero density limit and to the kinetic theory of gases [19] and is related to Chapman–Enskog theory [5], [19], [20]. Based on Chapman–Enskog theory and empirical BH3I-1 synthesis for the reduced collision integral, Chung et al. [21] did an em

• Modulators and methodologies have been developed to

  2020-08-06

  

  Modulators and methodologies have been developed to control ubiquitination. Examples include small molecule inhibitors that target E3 ligases–such as MDM2 and inhibitor of apoptosis proteins (IAPs)–or DUBs., Much research has focused on E3 ligases or DUBs. Moreover, research on protein knockdown us

• br EBI An Endogenous TM

  2020-08-05

  

  EBI2: An Endogenous 7TM Receptor Manipulated by EBV EBI2 was identified in 1993, when Kieff and colleagues used subtractive hybridization of DNA from Burkitt\'s lymphoma cells to screen for upregulated genes in EBV-infected cells. They found, being more than 200-fold upregulated (hence the name:

• While our findings to our knowledge

  2020-08-05

  

  While our findings, to our knowledge, are the first to show a direct relationship between the affinity of the E2 for the RING domain and substrate mono- versus polyubiquitination, our results are consistent with observations made in a number of previous studies. As mentioned above, a possible correl

11560 records 499/771 page Previous Next First page 上5页 496497498499500 下5页 Last page