• Introduction Hepatocellular carcinoma HCC is the

  2021-11-19

  

  Introduction Hepatocellular carcinoma (HCC) is the fifth most lethal malignant tumor worldwide and is the second leading cause of cancer-related death [1]. For HCC patients, PPM-18 virus (HBV) infection is the important causative risk factor in Asia-Pacific regions [[2], [3], [4]]. In China, more

• br Activation of soluble guanylate cyclase The

  2021-11-19

  

  Activation of soluble guanylate cyclase The molecular steps involved in sGC activation have evolved significantly over the last several years. The key studies are outlined below, but here we provide an overall summary. The activation mechanism of sGC was initially proposed to be relatively simple

• Initial experiments confirmed that RBC effectively inhibited

  2021-11-19

  

  Initial experiments confirmed that RBC8 effectively inhibited both RalA and RalB activation in an identical, dose-dependent manner following platelet stimulation with the GPVI-specific ligand, CRP (Fig. 1Ai). Non-specific, upper bands were observed when immunoblotting for activated RalB, with the sp

• The role of the cyclic AMP regulated exchange factor Epac

  2021-11-19

  

  The role of the cyclic AMP regulated exchange factor Epac1 is emerging in cancer (Almahariq et al., 2015, Banerjee and Cheng, 2015, Parnell et al., 2015, Parnell et al., 2015, Schmidt et al., 2013). Interestingly, in cancer cell migration, activation of Epac1 can be linked to activation of Rac. As s

• Acknowledgments Financial support from the National Natural

  2021-11-19

  

  Acknowledgments Financial support from the National Natural Science Foundation of China (81730094, 81473262 and 81573299) is gratefully acknowledged. This project was also supported by the “111 Project” from the Ministry of Education of China, the State Administration of Foreign Expert Affairs of C

• To effectively evaluate prospective mechanisms

  2021-11-19

  

  To effectively evaluate prospective mechanisms by which chronic HIV infection induces pulmonary fibrotic changes in humans, we confirmed that predisposition to fibrotic change in older individuals could be mimicked in a mouse model. Hydroxyproline is a nonessential amino Epigenetics Compound Library

• br Materials and methods br

  2021-11-19

  

  Materials and methods Results Discussion The redox domain that spans the region between amino Methotrexate positions 35 and 127 of the major human AP endonuclease, APE1, regulates the sequence-specific DNA binding of various transcription factors [[52], [85]]. The existent crystal structur

• Capillary monolithic columns obtained by in situ polymerizat

  2021-11-19

  

  Capillary monolithic columns obtained by in situ polymerization have been developed rapidly as an efficient chromatographic stationary phase, which exhibits excellent reproducibility, reliable stability and fast transfer kinetics [18]. Recently, it has been extensively applied in capillary liquid ch

• Throughout the last few decades evidence has accumulated

  2021-11-18

  

  Throughout the last few decades, evidence has accumulated indicating that NTTs, whose primary location is the cell surface, are subject to a series of regulatory processes of intracellular traffic to and from the membrane (Robinson and Jackson, 2016; Vaughan and Foster, 2013). In addition, lateral m

• A localization of GK to both a

  2021-11-18

  

  A localization of GK to both a cytoplasmic and perinuclear area of normal rat pancreatic beta-cells was reported in 1996 (Noma et al., 1996), which changed on acute hyperglycemia to a more diffuse staining throughout the cytoplasm. The localization of GK within the nucleus was first reported by Mura

• When PKC was applied alone it attenuated the

  2021-11-18

  

  When PKC19–31 was applied alone, it attenuated the activity run-down following excision. Furthermore, the activity induced by addition of PKC19–31 during PMA treatment in many cases was higher than in controls. Accordingly, in our experimental conditions, the mechanism which underlays channel inhibi

• An advantage of photolabeling with tritiated photoprobes fol

  2021-11-18

  

  An advantage of photolabeling with tritiated photoprobes followed by microsequencing with Edman degradation is the ability to both identify the photolabeled Chlorambucil and to quantify photoincorporation which enables assessment of pharmacological specificity and allosteric interactions with other

• In recent years it was

  2021-11-18

  

  In recent years, it was discovered in animals that certain types of non-apoptotic cell death are strictly dependent on iron and ROS. The term ‘ferroptosis’, derived from the Greek word ‘ptosis’ (falling) and the Latin word ‘ferrum’ (iron), is coined to describe such cell death phenomena. Cytoplasmi

• br Conclusions br Conflicts of

  2021-11-18

  

  Conclusions Conflicts of interest Funding The research work was partially supported by National Science Center (Contract Grant Number: UMO-2015/19/B/NZ1/00332). Introduction Frusectose-1, 6-bisphosphatase (FBPase) has long been recognized as a potential therapeutic target for the treatm

• However at variance with the well

  2021-11-18

  

  However, at variance with the well-studied R form of FBP1 which is flat, the R state of FBP2 is diametrically different, with a perpendicular orientation of the upper and lower dimers (Barciszewski et al., 2016). The cruciform-like R state of FBP2 is stabilized by a unique hydrophobic motif called ‘

11559 records 241/771 page Previous Next First page 上5页 241242243244245 下5页 Last page