• The development of metabolic stable non peptidergic galanin

  2022-01-12

  

  The development of metabolic stable, non-peptidergic galanin agonists could be the basis to clinical diagnosis and treatment of tumors with high levels of galanin receptor expression like gliomas and pituitary tumors. As for gliomas, penetration of the blood brain barrier by the compounds might be p

• Isoflurane administration during i t procedures can complica

  2022-01-12

  

  Isoflurane administration during i.t. procedures can complicate the interpretation of our results since isoflurane has been shown to have both neuroprotective and neurotoxic effects (Jiang et al., 2017). Isoflurane pretreatment has been implicated as having protective effects in ischemia in animal m

• The G protein coupled receptor GPR also called FFAR

  2022-01-12

  

  The G protein-coupled receptor, GPR40 (also called FFAR1) responds to medium and long chain unsaturated fatty acids, resulting in increase of insulin secretion during elevated glucose levels. The glucose dependency of insulin secretion makes this receptor a very good target for developing therapies

• The iAs mainly metabolized in

  2022-01-12

  

  The iAs mainly metabolized in the liver to generate MMA and DMA. DMA, MMA and iAs were excreted through the urine (Khaleghian et al., 2014; Wei et al., 2017a). Pearson correlation coefficient was used to explore associations between concentrations of three arsenic species in urine and gene expressio

• In order to establish proper folding and enzymatic activity

  2022-01-12

  

  In order to establish proper folding and enzymatic activity, G9a and GLP methyltransferases each contain four structural zinc ions. Both Participants contain two distinguishable types of zinc fingers; three Zn(II) ions are chelated in a triangular cluster by 9 cysteines (b, top left), whereas one Z

• br Acknowledgments The work in the Vancurova lab is supporte

  2022-01-12

  

  Acknowledgments The work in the Vancurova lab is supported by St John’s University, and by NIHCA202775 grant. HDACs are Epigenetic Achilles’ Heels in Tumors with ICLs On the one hand, proficient and accurate DNA repair mechanisms ensure the genomic integrity of cells. On the other hand, the D

• br Acknowledgements This work was financially

  2022-01-12

  

  Acknowledgements This work was financially supported by the National Natural Science Foundation of China (Grant No. 81803033) and the “Double First-Class” University project (CPU2018GF02). Introduction Atrial fibrillation (AF) is the most common progressive cardiac rhythm disorder. Studies ha

• The majority of HCV unaware individuals for

  2022-01-12

  

  The majority of HCV-unaware individuals, for which HCV RNA was obtainable, had active HCV infection and overall almost one-fifth of them had advanced liver disease according to the FIB-4 score; these persons can be classified as having a late HCV diagnosis and are in immediate need of HCV treatment

• DC260126 The crystal structures of plant class

  2022-01-12

  

  The crystal structures of plant class ADH3/GSNOR from Arabidopsis thaliana (AtGSNOR) and Solanum lycopersicum cv. Amateur (SlGSNOR) with bound substrates and cofactors revealed important differences between plant and human enzyme, namely within the substrate-binding pocket. GSNOR are unusually homod

• br Funding This work was partially supported

  2022-01-12

  

  Funding This work was partially supported by the National Institute on Alcohol Abuse and Alcoholism, award R00AA021264, startup funds from the Department of Immunology, Herbert Wertheim College of Medicine, and the Office of Research and Economic Development at FIU, and pilot funds from Dr. Werth

• Several investigators including ourselves have previously sh

  2022-01-12

  

  Several investigators including ourselves have previously shown, that allogeneic HLA-DPB1 class II-alleles are powerful leukemia rejection Fmoc-Gly-OPfp for CD4 T-cell therapy following allogeneic hematopoietic stem cell transplantation (Herr et al., 2017, Rutten et al., 2008, Stevanovic et al., 20

• AI-10-49 A high throughput screening campaign of the Lilly

  2022-01-12

  

  A high-throughput screening campaign of the Lilly corporate compound collection led to the discovery of as potent and selective inhibitor of GlyT1 (IC=45nM, GlyT2 IC>30,000nM). In addition to the characteristic -methyl glycine moiety as acidic head group and the novel ethanolamine linker, also cont

• By regulation of synaptic glutamate concentration glutamate

  2022-01-11

  

  By regulation of synaptic glutamate concentration, glutamate transporters play an important role in limiting glutamate signaling and controlling the activation of glutamate receptors (Rimmele and Rosenberg, 2016). Reduced glutamate transport is thought to underlie the pathogenesis of numerous neurol

• br Materials and methods br Results br Discussion

  2022-01-11

  

  Materials and methods Results Discussion The glucose transporter GLUT1 can be acutely activated or inhibited in L929 fibroblast Mometasone furoate receptor by a wide variety of reagents or nutrient conditions [[9], [10], [11], [12],36,50]. This abrupt change in the activity of GLUT1 occurs

• Topotecan HCl mg Though regulation of ghrelin interaction wi

  2022-01-11

  

  Though regulation of ghrelin interaction with GHSR has not been described previously, a precedent for a similar regulatory mechanism exists in the form of the interaction between Agouti-Related Protein (AgRP) and melanocortin receptor subtypes MC3R and MC4R (Ollmann, 1997). AgRP is produced by hypot

11558 records 209/771 page Previous Next First page 上5页 206207208209210 下5页 Last page