• While it has been reported that the combination therapy

  2019-06-14

  

  While it has been reported that the combination therapy of As2O3 and ATRA is highly effective not only as the front-line treatment [6], but also in relapsed and treatment-refractory APL patients [7], showing fewer adverse events than the combination of ATRA and chemotherapeutic drugs, the efficacy a

• The further investigation was performed

  2019-06-13

  

  The further investigation was performed by using MEM-M6/6 antibody to observe the linkage exits between CD147 and P-gp activity by intracellular Rho123 accumulation. MEM-M6/6 treatment did not alter Rho123 accumulation in drug-resistant K562/ADR cells. In contrast, the fluorescence intensity of Rho1

• br Environmental pollution is a global problem

  2019-06-13

  

  Environmental pollution is a global problem and the subject of increasing worldwide public health concern. In particular, air pollution is regarded as the largest single environmental risk to health. More than 80% of people living in urban areas that monitor air pollution are exposed to air qualit

• br Conclusions br Study limitations br Conflict of interest

  2019-06-13

  

  Conclusions Study limitations Conflict of interest Introduction Dabigatran etexilate, an orally administered pro-drug, is rapidly converted by a serum esterase to dabigatran, a potent, direct, and competitive inhibitor of thrombin. It has an absolute bioavailability of 6.5% and a serum h

• Curative treatments which include surgical resection percuta

  2019-06-13

  

  Curative treatments, which include surgical resection, percutaneous ablation and liver transplantation, were considered as the optimal treatment for patients with very early/early stage HCC by BCLC criteria. Furthermore, advances in liver surgery make the resection of large and/or multifocal HCC pos

• ECG changes emerged when creating a substrate map of the

  2019-06-13

  

  ECG changes emerged when creating a substrate map of the LV (Fig. 2A), near the inferior mitral valve. A long transseptal sheath was introduced into the LV under intracardiac echocardiography guidance without causing an air-embolism. While performing the LV substrate mapping, the long transseptal sh

• Paying now rather than forever has never been as

  2019-06-13

  

  Paying now rather than forever has never been as relevant as a global health solution to the HIV pandemic than in 2013. The relative success of the ongoing replenishment session for the Global Fund is a positive signal, although still insufficient considering the evidence-based targets that are set

• Transformation of sanitation related knowledge into routine

  2019-06-13

  

  Transformation of sanitation-related knowledge into routine practice is hindered by traditional mindsets and the absence of awareness and an attitude to learn. Poverty has been described as a barrier to following safe hygiene practices. Regular use of footwear is equally important for the prevention

• Cepheid s GeneXpert system achieved recognition as a

  2019-06-13

  

  Cepheid\'s GeneXpert system achieved recognition as a rapid molecular test to identify active tuberculosis and rifampicin resistance, a marker for multidrug-resistant tuberculosis. So far, more than 13 million Xpert /rifampicin (MTB/RIF) tests have been done worldwide. However, the primary criticism

• Outra implica o envolvida com as os

  2019-06-13

  

  Outra implicação envolvida com as os e que tem sido uma das principais bandeiras levantada por entidades contrárias é calcitonin receptor considerada terceirização da saúde pública. A terceirização foi assumida por alguns agentes envolvidos no processo, como o ex-secretário de saúde paulista e sanit

• El n mero de correspondiente al segundo semestre de ofrece

  2019-06-13

  

  El número 59 de , correspondiente al segundo semestre de 2014, ofrece la sección Temas y Problemas de Nuestra América, en el que se encuentran artículos relacionados con asuntos de gran relevancia actual. En primer lugar, el texto “Nuevas narrativas constitucionales en Bolivia y Ecuador: el buen viv

• br Conclusion br Introduction Multiple myeloma is a

  2019-06-13

  

  Conclusion Introduction Multiple myeloma is a malignant plasma cell disorder, comprising approximately 10% of all haematological malignancies, and its incidence is increasing [1]. The pathogenesis is complex, culminating in malignant transformation of clonal plasma cells. The aetiology is not

• In Rachel Lowe and colleagues show the

  2019-06-13

  

  In , Rachel Lowe and colleagues show the potential of application of climate services for health to dengue in the city of Machala, El Oro Province, Ecuador, where dengue is hyperendemic and transmitted throughout the year with co-circulation of all four dengue serotypes. Machala is an ideal site for

• br Conclusions br Conflict of

  2019-06-12

  

  Conclusions Conflict of interest Introduction Gastrointestinal stromal tumor (GIST) arises from the mesenchymal tissue of the gastrointestinal tract. The annual incidence of this condition is 7 cases per million people in the West. However, the incidence could in fact be higher in Asian pop

• The authors of the NCCN non small

  2019-06-12

  

  The authors of the NCCN non-small cell lung cancer guidelines provide the most guidance about radiotherapy dosing for painful bone metastases of any of the primary sites evaluated [39]. Bone metastases due to non-small cell lung cancer are separated into those “with soft tissue mass” versus those “w

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